Polymerase chain reaction (PCR) is one of the most commonly performed laboratory procedures. This technique, used to amplify DNA or RNA sequences, is integral to a host of industries and environments, including healthcare, research, forensics, and agriculture. This powerful technique can be used to measure levels of gene activation, discover mutations in samples from patients with cancer, and identify sources of bacterial infection. However, despite recent advances in PCR technology, labeling PCR tubes remains problematic.
CRISPR/Cas9, originally discovered in 1987 by a team of Japanese scientists and later refined by Jennifer Doudna in 2012, is a gene-editing tool that can cut and paste any genomic sequence, either in vitro or in vivo. It’s a system that relies on clustered regularly interspaced short palindromic repeats (CRISPR) to recognize foreign DNA and is mainly used in bacteria to fight off viral infection. This tool has garnered a lot of attention recently as researchers have tailored CRISPR/Cas9 to edit animal genomes in ways that were previously impossible or inefficient, revolutionizing genetic and biomedical research. CRISPR/Cas9 has become a crucial resource for labs who require stable cell lines or mice with knockouts, knock-ins, or gene mutations, able to drive constitutive gene activation or to edit micro-RNA and long-noncoding RNA.
As the complexity of pre-clinical and clinical testing has increased over the last decade, labs have been challenged with collecting, processing, and storing more and more samples on a daily basis. To minimize errors and keep lab efficiency strong, labs depend on robust identification solutions, consisting of high-quality barcode labels, tags, and tapes. The laboratory environment has been characterized by ongoing rapid and dramatic innovation, including the implementation of high-throughput techniques that often require the labeling of large amounts of small sample tubes, such as cryovials, microtubes, and PCR tubes.